It’s a little-known fact: Missouri was once one of the most exciting and thriving wine states in the U.S.—especially in the mid and late 19th century. But even a hundred years later—in 1980—Missouri had another wine-claim-to-fame: Augusta, Missouri, became the first AVA (American Viticultural Area) in the entire U.S. Today, Missouri is ground zero for all kinds of unique and fascinating wines made from native American grape varieties as well as hybrids that most of us have never heard of, or tasted.